Skupina integrativní a systémové biologie komplexních onemocnění

Vedoucí / Head: prof. MUDr. Ondřej Šeda, Ph.D.

Ondřej Šeda on ResearchGate

1 Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension Hamet, P; Merlo, E; (...); Cowley, AW May 2005 |       AMERICAN JOURNAL OF HUMAN GENETICS 76 (5) , pp.815-832

remove_circle_outline 2 A Common Variant of the FTO Gene Is Associated With Not Only Increased Adiposity but Also Elevated Blood Pressure in French Canadians Pausova, Z; Syme, C; (...); Paus, T Jun 2009 |       CIRCULATION-CARDIOVASCULAR GENETICS 2 (3) , pp.260-269

remove_circle_outline 3 Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1 Zarrouki, B; Benterki, I; (...); Poitout, V Mar 2014 |       DIABETES 63 (3) , pp.982-993

remove_circle_outline 4 Systematic, genome-wide, sex-specific linkage of cardiovascular traits in french Canadians Seda, O; Tremblay, J; (...); Hamet, P Apr 2008 |       HYPERTENSION 51 (4) , pp.1156-1162

remove_circle_outline 5 Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndrome Sedová, L; Seda, O; (...); Krenová, D May 2007 |       AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 292 (5) , pp.E1318-E1324

remove_circle_outline 6 Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice Beetz, N; Harrison, MD; (...); Hein, L Dec 2009 |       JOURNAL OF CLINICAL INVESTIGATION 119 (12) , pp.3597-3612

remove_circle_outline 7 A comparative study on the applicability of six radiant floor, wall, and ceiling heating systems based on thermal performance analysis Oravec, J; Ondrej, S; (...); Mohapl, M Jan 2021 (Early Access) |       JOURNAL OF BUILDING ENGINEERING 36

remove_circle_outline 8 Dynamic genetic architecture of metabolic syndrome attributes in the rat Seda, O; Liska, F; (...); Kren, V Apr 14 2005 |       PHYSIOLOGICAL GENOMICS 21 (2) , pp.243-252

remove_circle_outline 9 New apolipoprotein A-V: Comparative genomics meets metabolism Seda, O and Sedová, L 2003 |       PHYSIOLOGICAL RESEARCH 52 (2) , pp.141-146

remove_circle_outline 10 Downregulation of Plzf Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat Liska, F; Landa, V; (...); Pravenec, M Jun 2017 |       HYPERTENSION 69 (6) , pp.1084-+

remove_circle_outline 11 Rat inbred PD/Cub strain as a model of dyslipidemia and insulin resistance Sedová, L; Kazdová, L; (...); Kren, V 2000 |       FOLIA BIOLOGICA 46 (3) , pp.99-106

remove_circle_outline 12 Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse Nikpay, M; Seda, O; (...); Hamet, P Jun 2012 |       HYPERTENSION RESEARCH 35 (6) , pp.585-591

remove_circle_outline 13 A 14-gene region of rat chromosome 8 in SHR-derived polydactylous congenic substrain affects muscle-specific insulin resistance, dyslipidaemia and visceral adiposity Seda, O; Liska, F; (...); Kren, V 2005 |       FOLIA BIOLOGICA 51 (3) , pp.53-61

remove_circle_outline 14 ZBTB16 and Metabolic Syndrome: a Network Perspective Seda, O; Sedová, L; (...); Bendlová, B 2017 |       PHYSIOLOGICAL RESEARCH 66 , pp.S357-S365

remove_circle_outline 15 Inhibition of Lipolysis Ameliorates Diabetic Phenotype in a Mouse Model of Obstructive Sleep Apnea Weiszenstein, M; Shimoda, LA; (...); Polak, J Aug 1 2016 |       AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 55 (2) , pp.299-307

remove_circle_outline 16 Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight Shamansurova, Z; Tan, P; (...); Lavoie, JL Oct 2016 |       MOLECULAR METABOLISM 5 (10) , pp.959-969

remove_circle_outline 17 Association of age-dependent height and bone mineral density decline with increased arterial stiffness and rate of fractures in hypertensive individuals EL-Bikai, R; Tahir, MR; (...); Hamet, P Apr 2015 |       JOURNAL OF HYPERTENSION 33 (4) , pp.727-735

remove_circle_outline 18 Serum miR-33a is associated with steatosis and inflammation in patients with nonalcoholic fatty liver disease after liver transplantation Erhartova, D; Cahova, M; (...); Trunecka, P Nov 8 2019 |       PLOS ONE 14 (11)

remove_circle_outline 19 Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome Sedova, L; Seda, O; (...); Kazdova, L May 2004 |       INTERNATIONAL JOURNAL OF OBESITY 28 (5) , pp.719-725

remove_circle_outline 20 Metabolic characterization of insulin resistance syndrome feature loci in three brown Norway-derived congenic strains Seda, O; Sedová, L; (...); Kren, V 2002 |       FOLIA BIOLOGICA 48 (3) , pp.81-88

remove_circle_outline 21 Rosiglitazone fails to improve hypertriglyceridemia and glucose tolerance in CD36-deficient BN.SHR4 congenic rat strain Seda, O; Kazdova, L; (...); Kren, V Jan 15 2003 |       PHYSIOLOGICAL GENOMICS 12 (2) , pp.73-78

remove_circle_outline 22 PPARA Intron Polymorphism Associated with Power Performance in 30-s Anaerobic Wingate Test Petr, M; St'astny, P; (...); Kohlíková, E Sep 8 2014 |       PLOS ONE 9 (9)

remove_circle_outline 23 Plzf as a Candidate Gene Predisposing the Spontaneously Hypertensive Rat to Hypertension, Left Ventricular Hypertrophy, and Interstitial Fibrosis Liska, F; Mancini, M; (...); Kren, V Jan 2014 |       AMERICAN JOURNAL OF HYPERTENSION 27 (1) , pp.99-106

remove_circle_outline 24 Cell-free DNA in plasma as an essential immune system regulator Korabecna, M; Zinkova, A; (...); Seda, O Oct 15 2020 |       SCIENTIFIC REPORTS 10 (1)

 The overall aim of our project is the systematic deconstruction of eco-genomic architecture of metabolic syndrome. We are pursuing this goal using genetically designed rat models with modulated gene expression (single genes or metabolic/signaling pathways). We are particularly focusing on four major aspects of metabolic syndrome eco-genomic “landscape”.

Early environment and metabolic programming of metabolic syndrome.

Our initial studies showed that the metabolic and hemodynamic outcomes of early environment challenges are to a certain extent dependent on the genomic background. We are set to determine major metabolic (biomarkers), transcriptomic (transcripts, pathways) and epigenomic (methylation) features related to developmental drivers of particular subsets of metabolic syndrome as seen in clinical setting.

Genetical genomics of metabolic syndrome.

This approach involves identification of signaling and expression modules playing a role in pathogenesis of metabolic syndrome and its aspects. By combining the existing and newly generated –omics level data from designed rat models of metabolic syndrome we are seeking the sex, age and organ-specific expression and signaling networks and playing crucial roles in pathogenesis of the metabolic syndrome.

Nutrigenomics and pharmacogenomics of metabolic syndrome.

Reflecting the complex network of dietary and pharmacological influences that only together with the genomic background make up the clinical presentation of metabolic syndrome in real life, we are systematically dissecting the diet-modulated, pharmacogenetic interactions we have previously described e.g. for the antidiabetic drug rosiglitazone. We are testing the effects of westernized diets and commonly used drugs known to affect features of metabolic syndrome when acting on specific genomic backgrounds in the designed rat models.

Towards integrative eco-genomics of metabolic syndrome.

By integration of the results from the above project and the available date we aim to proceed beyond the identification of individual risk and protective variants using the tools of system biology (analysis and modeling of genetic and signaling networks). This effort should lead us towards identification of functional genomic signatures connected with manifestation of specific forms of metabolic syndrome.