Skupina genové regulace
Vedoucí: Ing. Tomáš Vacík, Ph.D.
Our research is focused on elucidating
the molecular mechanisms behind various cellular processes involved in transcriptional
regulation, epigenetics and chromatin structure. We are using mainly molecular
biology methods and in silico
approaches to study the function of various nuclear chromatin regulating
proteins and of their frequently overlooked alternative isoforms. Since
misregulation of various alternative intronic promoters is known to be
associated with developmental defects and human diseases, we are interested in finding
out more about transcriptional regulation of selected intronic promoters and about the
consequences of their misregulation.
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